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Been testing out pairing NMN and NR together for the past 8 months and honestly the dual approach on my NAD+ levels has been amazing - I take 1000mg of each on empty stomach and my mitochondrial function feel like they've reverted to my 30s, plus my doctor confirmed my biomarkers show major gains in insulin sensitivity and the pairing seems to be more effective than either nicotinamide mononucleotide or nicotinamide riboside alone since they access distinct cellular uptake mechanisms with NMN using the Slc12a8 transporter while NR goes through the salvage pathway so you're essentially hitting various routes of NAD+ restoration which is crucial for SIRT1 function, cellular health optimization (faq.sectionsanywhere.com) maintenance, and reversing the natural NAD+ decline with age that kicks in around 40 - definitely recommend adding quercetin as a CD38 enzyme inhibitor to reduce NAD+ degradation and maybe some TMG for methyl donor function.
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