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Been testing out pairing NMN and NR together for the past 8 months and honestly the dual approach on my NAD+ levels has been amazing - I take 1000mg of each on empty stomach and my mitochondrial function feel like they've reverted to my 30s, plus my doctor confirmed my biomarkers show major gains in insulin sensitivity and the pairing seems to be more effective than either nicotinamide mononucleotide or nicotinamide riboside alone since they access distinct cellular uptake mechanisms with NMN using the Slc12a8 transporter while NR goes through the salvage pathway so you're essentially hitting various routes of NAD+ restoration which is crucial for SIRT1 function, cellular health optimization (faq.sectionsanywhere.com) maintenance, and reversing the natural NAD+ decline with age that kicks in around 40 - definitely recommend adding quercetin as a CD38 enzyme inhibitor to reduce NAD+ degradation and maybe some TMG for methyl donor function.
Great post about combining NAD+ precursors! I've been experimenting with taking both NMN and NR together for about six months now and honestly the synergistic effect is noticeable compared to when I was just taking one or the other - my understanding is that NMN works through the Slc12a8 transporter while NR gets converted by NRK1 and NRK2 enzymes so they're hitting different pathways in NAD+ biosynthesis which makes total sense for boosting cellular energy metabolism boosters - http://www.china-hnyr.com/, production and mitochondrial function more effectively than either supplement alone, plus I've read some interesting research suggesting that this combination approach might be better for sirtuin activation and DNA repair since you're essentially giving your cells multiple routes to restore NAD+ levels that naturally decline with age, though I'm curious if anyone else has tried stacking them with quercetin as a CD38 enzyme inhibitor to prevent NAD+ degradation because I'm thinking about adding that to my longevity supplement routine along with some TMG for methylation support - currently doing 500mg NMN in the morning and 300mg NR in the evening and definitely feeling improvements in energy levels and muscle recovery after workouts, though I know the bioavailability question is still being debated in the research community.
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